Map3k7 ELISA Kit for Mouse(Mus musculus) | EIAab.comMap3k7 ELISA Kit for Mouse(Mus musculus)

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Map3k7 (Gene name),

Mitogen-activated protein kinase kinase kinase 7 (Protein name ), M3K7_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Map3k7(Tak1);

Protein name:

Mitogen-activated protein kinase kinase kinase 7;

Alternative:

Transforming growth factor-beta-activated kinase 1(TGF-beta-activated kinase 1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Identified in the TRIKA2 complex composed of MAP3K7, TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Interacts with PPM1L. Interaction with PP2A and PPP6C leads to its repressed activity. Interacts with TRAF6 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with TAOK1 and TAOK2; interaction with TAOK2 interferEs with MAP3K7 interaction with IKKA, thus preventing NF-kappa-B activation. Interacts with WDR34 (via WD domains). Interacts with RBCK1. Interacts with TGFBR1; induces MAP3K7 activation by TRAF6 (By similarity). Interacts with CYLD. Interacts with MAPK8IP1 and VRK2.

Function:

Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

579

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

579:

NKSLSTYYQQ | CKKQLEVIRS | QQQKRQGTS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:26409

Pfam:

PF07714

String:

Q62073

UniGene:

Mm.258589

SMR:

Q62073

Uniprot:

Q62073

FOR

ELISA Kit for Mouse Mitogen-activated protein kinase kinase kinase 7

Cat.:

E10349b

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Mitogen-activated protein kinase kinase kinase 7

Cat.:

E10349r

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96T

ELISA Kit for Mouse Mitogen-activated protein kinase kinase kinase 7

Cat.:

E10349h

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96T

ELISA Kit for Mouse Mitogen-activated protein kinase kinase kinase 7

Cat.:

E10349m

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96T

CLIA Kit for Mouse Mitogen-activated protein kinase kinase kinase 7

Cat.:

U10349m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Mitogen-activated protein kinase kinase kinase 7

Cat.:

U10349r

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Mitogen-activated protein kinase kinase kinase 7

Cat.:

U10349b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Mitogen-activated protein kinase kinase kinase 7

Cat.:

U10349h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 7

Cat.:

P10349Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 7

Cat.:

P10349Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 7

Cat.:

P10349Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Mitogen-activated protein kinase kinase kinase 7

Protein for Mouse Mitogen-activated protein kinase kinase kinase 7

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction."
Yamaguchi K. , Shirakabe K. , Shibuya H. , Irie K. , Ohishi I. , Ueno N. , Taniguchi T. , Nishida E. , Matsumoto K.
Science270:2008-2011(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
2.

"BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6."
Kimura N. , Matsuo R. , Shibuya H. , Nakashima K. , Taga T.
J. Biol. Chem.275:17647-17652(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SMAD6
3.

"Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon)."
Li M.G. , Katsura K. , Nomiyama H. , Komaki K. , Ninomiya-Tsuji J. , Matsumoto K. , Kobayashi T. , Tamura S.
J. Biol. Chem.278:12013-12021(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPM1L
4.

"X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1)."
Kaur S. , Wang F. , Venkatraman M. , Arsura M.
J. Biol. Chem.280:38599-38608(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;UBIQUITINATION;PROTEASOMAL DEGRADATION
5.

"Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses."
Reiley W.W. , Jin W. , Lee A.J. , Wright A. , Wu X. , Tewalt E.F. , Leonard T.O. , Norbury C.C. , Fitzpatrick L. , Zhang M. , Sun S.C.
J. Exp. Med.204:1475-1485(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;INTERACTION WITH CYLD;DEUBIQUITINATION BY CYLD
6.

"Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1."
Blanco S. , Santos C. , Lazo P.A.
Mol. Cell. Biol.27:7273-7283(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VRK2 AND MAPK8IP1
7.

"Ubiquitin-mediated activation of TAK1 and IKK."
Adhikari A. , Xu M. , Chen Z.J.
Oncogene26:3214-3226(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ENZYME REGULATION
8.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
9.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-389 AND SER-412;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"The TAK1-TRAF6 signalling pathway."
Landstrom M.
Int. J. Biochem. Cell Biol.42:585-589(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ENZYME REGULATION;REVIEW ON FUNCTION

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